Malignant Acanthosis Nigricans Associated with Ovarian Carcinoma

Prof C Oh1, Dr C Kim2
Department of Dermatology, School of Medicine, GyeongSang National University Hospital1
Department of Dermatology, School of Medicine, GyeongSang National University Hospital2

Malignant acanthosis nigricans is a disease that has an abrupt onset and is most commonly associated with gastric adenocarcinoma. It can occur simultaneously, before, or after the onset of internal malignancy. Malignant accanthosis nigricans has occurred as a paraneoplastic phenomenon in other carcinoma, rarely reported in gynecologic carcinoma. We described a rare association of malignant acanthosis nigricans, hyperkeratosis of the palms and soles, and papillomatous oral mucosa in patient with ovarian cancer. The presences of acanthosis nigricans in conjunction with tripe palms is highly suggestive of an internal malignancy and necessitate an extensive investigation in order to discover the underlying malignancy include gynecologic carcinoma.

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AFMW Author